Evaluation of hepatoprotective activity of stem bark of Pterocarpus marsupium Roxb

نویسندگان

  • K. L. Mankani
  • V. Krishna
  • B. K. Manjunatha
  • S. M. Vidya
  • S. D. Jagadeesh Singh
  • Y. N. Manohara
چکیده

Objective: To evaluate the hepatoprotective activity of Pterocarpus marsupium stem bark extracts against carbon tetrachloride (CCl 4 )-induced hepatotoxicity. Materials and methods: Hepatotoxicity was induced in male Wistar rats by intraperitoneal injection of CCl 4 (0.1 ml/kg/day for 10 days). Methanol and aqueous extracts of P. marsupium stem bark were administered to the experimental rats (25 mg/kg/day, p.o. for 14 days). The hepatoprotective effect of these extracts was evaluated by the assay of liver function biochemical parameters (total bilirubin, serum protein, alanine aminotransaminase, aspartate aminotransaminase, and alkaline phosphatase activities) and histopathological studies of

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تاریخ انتشار 2005